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Silvia Sparapani
Research
Silvia Sparapani received a degree and MSc in Chemistry at the Universita' degli Studi di Camerino, Italy and joined the group of research of Prof. I. Antonini, working on the synthesis and biological evaluation of DNA binding ligands. As part of her PhD studies, she did postgraduate work at the University of Vermont, USA, investigating, under the supervision of Emeritus Professor A. Paul Krapcho, novel G-quadruplex interacting phenanthroline derivatives. She then returned to Antonini's group and completed her PhD in Medicinal Chemistry at the University of Camerino, Italy. In 2006 she joined the Neidle group as a research fellow, focussing on the synthesis and biophysical evaluation of novel disubstituted acridines targeting telomeric G-quadruplex. In 2008 she has been awarded a Postdoctoral C. W. Maplethorpe Fellowship and is currently working at the School of Pharmacy, associated with Prof. Neidle's group. Her aim is to generate molecules that are selective for particular quadruplex targets, using novel medicinal chemistry approaches.
Publications
- Displacement reactions of 2-chloro- and 2,9-dichloro-1,10-phenanthroline: synthesis of a sulfur-bridged bis-1,10-phenanthroline macrocycle and a 2,2'-amino-substituted-bis-1,10-phenanthroline. Krapcho, A.P.; Sparapani, S.; Leenstra, A.; Seitz, J.D. Tetrahedron Lett. 2009, 50(26), 3195-3197.
- Facile acidic hydrolysis and displacement reactions of 2-chloro- and 2,9-dichloro-1,10-phenanthroline, Krapcho, A. P., Sparapani, S. J. Het. Chem. 2008, 45(4), 1167-1170.
- Synthesis and Reactions of 1,10-phenanthroline-2(1H)-thione: a Facile Synthesis of 2,2'-thiobis-1,10-phenanthroline, Krapcho, A.P., Sparapani, S., Boxer, M. Tetrahedron Lett. 2007, 48 (32), 5593-5597.
- Synthesis and Biological Evaluation of New Asymmetrical Bisintercalators as Potential Antitumor Drugs
Antonini, I.; Santoni, G.; Lucciarini, R.; Amantini, C.; Sparapani, S.; Magnano, A.
J. Med. Chem. 2006, 49(24), 7198-7207
- Rational Design, Synthesis and Biological Evaluation of Bis(pyrimido[5,6,1-de]acridines) and Bis(pirazolo[3,4,5-kl]acridine-5-carboxamides) as New Anticancer Agents, Antonini, I.; Polucci, P.; Magnano, A.; Sparapani, S.; Martelli, S. J. Med. Chem. 2004, 47, 5244-5250.
- Rational Design, Synthesis and Biological Evaluation of 3H-naphtho[1,2,3-de]quinoline-2,7-diones: a New Class of Potential Antitumor Agents, Antonini, I.; Polucci, P.; Magnano, A.; Sparapani, S.; Martelli, S. Polish J. Chem. 2004, 78, 1019-1025.
- Synthesis and Biological Evaluation of Indazolo [4,3-bc]-[1,5]naphtyridines (10-aza-pyrazolo[3,4,5-kl]acridines): A New Class of Antitumor Agents, Magnano, A.; Sparapani, S.; Lucciarini R.; Mosca, M.; Amantini, C.; Santoni, G.; Antonini, I. Bioorg. & Med. Chem. 2004, 12, 5941-5947.