Tony Reszka

Research Interests:

• FRET and melting studies of G-quadruplex forming oligonucleotide sequences.
• Development of screening techniques for G-quadruplex binding ligands.
• Oligonucleotide synthesis and purification.
• Synthesis of DNA binding ligands.

Recent Publications

• Martins C, Gunaratnam M, Stuart J, Makwana V, Greciano O, Reszka AP, Kelland LR, Neidle S. Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. Bioorg Med Chem Lett. 2007 Jan 25; [Epub ahead of print]


• White EW, Tanious F, Ismail MA, Reszka AP, Neidle S, Boykin DW, Wilson WD. Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge. Biophys Chem 126(1-3):140-53, 2007.


• Redman JE, Ladame S, Reszka AP, Neidle S, Balasubramanian S. Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library. Org Biomol Chem. 4(23):4364-9, 2006.


• Fernando H, Reszka AP, Huppert J, Ladame S, Rankin S, Venkitaraman AR, Neidle S, Balasubramanian S. A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene. Biochemistry 45(25): 7854-7860, 2006.


• Rankin S, Reszka AP, Huppert J, Zloh M, Parkinson GN, Todd AK, Ladame S, Balasubramanian S, Neidle S. Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc 127(30): 10584-10589, 2005.


• Burger AM, Dai F, Schultes CM, Reszka AP, Moore MJ, Double JA, Neidle S. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res 65(4): 1489-1496, 2005.


• Harrison RJ, Reszka AP, Haider SM, Romagnoli B, Morrell J, Read MA, Gowan SM, Incles CM, Kelland LR, Neidle S. Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorg Med Chem Lett 14(23): 5845-5849, 2004.


• Harrison RJ, Cuesta J, Chessari G, Read MA, Basra SK, Reszka AP, Morrell J, Gowan SM, Incles CM, Tanious FA, Wilson WD, Kelland LR, Neidle S. Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors. J Med Chem 46(21): 4463-4476, 2003.


• Li JL, Harrison RJ, Reszka AP, Brosh RM Jr, Bohr VA, Neidle S, Hickson ID. Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. Biochemistry 40: 15194-15202, 2001.


• Read M, Harrison RJ, Romagnoli B, Tanious FA, Gowan SH, Reszka AP, Wilson WD, Kelland LR, Neidle S. Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors. Proc Natl Acad Sci USA 98: 4844-4849, 2001.