Hazel P, Huppert J, Balasubramanian S, Neidle S.
Loop-Length-Dependent Folding of G-Quadruplexes.
J Am Chem Soc 126(50): 16405-16415, 2004.


Harrison RJ, Reszka AP, Haider SM, Romagnoli B, Morrell J, Read MA, Gowan SM, Incles CM, Kelland LR, Neidle S.
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.
Bioorg Med Chem Lett 14(23): 5845-5849, 2004.


Mallena S, Lee MP, Bailly C, Neidle S, Kumar A, Boykin DW, Wilson WD.
Thiophene-based diamidine forms a "super" at binding minor groove agent.
J Am Chem Soc 126(42): 13659-13669, 2004.


Incles CM, Schultes CM, Kempski H, Koehler H, Kelland LR, Neidle S.
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells.
Mol Cancer Ther 3(10): 1201-1206, 2004.


Ladame S, Schouten JA, Stuart J, Roldan J, Neidle S, Balasubramanian S.
Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform.
Org Biomol Chem 2(20): 2925-2931, 2004.


Neidle S.
Stephen Neidle on cancer therapy and G-quadruplex inhibitors. Interview by Joanna De Souza.
Drug Discov Today 9(18): 778-781, 2004.


Schultes CM, Guyen B, Cuesta J, Neidle S.
Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.
Bioorg Med Chem Lett 14(16): 4347-4351, 2004.


Guyen B, Schultes CM, Hazel P, Mann J, Neidle S.
Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase.
Org Biomol Chem 2(7): 981-988, 2004.


Nguyen B, Hamelberg D, Bailly C, Colson P, Stanek J, Brun R, Neidle S, Wilson WD.
Characterization of a novel DNA minor-groove complex.
Biophys J 86(2): 1028-1041, 2004.


Caceres C, Wright G, Gouyette C, Parkinson G, Subirana JA.
A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions.
Nucleic Acids Res 32(3): 1097-1102, 2004.








Our work is supported by Cancer Research UK , The Association for International Cancer Research , The European Union and BBSRC.
We are based at The School of Pharmacy
Copyright © 2008 Cancer Research UK Biomolecular Structure Group