Campbell NH, Parkinson GN.
Crystallographic studies of quadruplex nucleic acids.
Methods. 2007 Dec;43(4):252-63.


Todd AK.
Bioinformatics approaches to quadruplex sequence location
Methods. 2007 Dec;43(4):246-51.


Reed JE, Neidle S, Vilar R.
Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex.
Chem Commun (Camb). 2007 Nov 14;(42):4366-8. Epub 2007 Aug 13.


Todd AK, Haider SM, Parkinson GN, Neidle S.
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter.
Nucleic Acids Res. 2007;35(17):5799-808. Epub 2007 Aug 24


Lee MP, Parkinson GN, Hazel P, Neidle S.
Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel.
J Am Chem Soc. 2007 Aug 22;129(33):10106-7. Epub 2007 Jul 28


Gunaratnam M, Greciano O, Martins C, Reszka AP, Schultes CM, Morjani H, Riou JF, Neidle S.
Mechanism of acridine-based telomerase inhibition and telomere shortening.
Biochem Pharmacol. 2007 Sep 1;74(5):679-89. Epub 2007 Jun 16.Click here to read


Manoj Munde, Michael Lee, Stephen Neidle, Reem Arafa, David W. Boykin, Yang Liu, Christian Bailly, and W. David Wilson
Induced Fit Conformational Changes of a "Reversed Amidine" Heterocycle: Optimized Interactions in a DNA Minor Groove Complex.
J. Am. Chem. Soc. 2007 129(17) pp 5688 - 5698


Milroy LG, Zinzalla G, Prencipe G, Michel P, Ley SV, Gunaratnam M, Beltran M, Neidle S.
Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.
Angew Chem Int Ed Engl. 2007;46(14):2493-6


Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ.
Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter.
J Am Chem Soc. 2007 Apr 11;129(14):4386-92. Epub 2007 Mar 16


Lech-Gustav Milroy, Giovanna Zinzalla, Giuseppe Prencipe, Patrick Michel, Steven V. Ley, Mekala Gunaratnam, Monica Beltran, Stephen Neidle,
Chemical Variation of Natural-Product-Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives
Angew Chem Int Ed Engl. 2007 Feb 23;46(14):2493-2496 [Epub ahead of print]


Parkinson GN, Ghosh R, Neidle S.
Structural Basis for Binding of Porphyrin to Human Telomeres.
Biochemistry. 2007 Mar 6;46(9):2390-7. Epub 2007 Feb 3.


Davies RJ, Malone JF, Gan Y, Cardin CJ, Lee MP, Neidle S.
High-resolution crystal structure of the intramolecular d(TpA) thymine-adenine photoadduct and its mechanistic implications.
Nucleic Acids Res. 2007;35(4):1048-53. Epub 2007 Jan 30.


Martins C, Gunaratnam M, Stuart J, Makwana V, Greciano O, Reszka AP, Kelland LR, Neidle S.
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
Bioorg Med Chem Lett. 2007 Apr 15;17(8):2293-8. Epub 2007 Jan 25








Our work is supported by Cancer Research UK , The Association for International Cancer Research , The European Union and BBSRC.
We are based at The School of Pharmacy
Copyright © 2008 Cancer Research UK Biomolecular Structure Group