Campbell NH, Parkinson GN, Reszka AP, Neidle S.
Structural Basis of DNA Quadruplex Recognition by an Acridine Drug
J. Am. Chem. Soc. 2008 ASAP Article


Neidle S, Parkinson GN.
Quadruplex DNA crystal structures and drug design.
Biochimie. 2008 Mar 19 [Epub ahead of print]


Haider SM, Parkinson GN, Neidle S.
Molecular Dynamics and Principal Components Analysis of Human Telomeric Quadruplex Multimers.
Biophys J. 2008 Mar 28 [Epub ahead of print]


Todd AK, Neidle S.
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements.
Nucleic Acids Res. 2008 Mar 19 [Epub ahead of print]


Cuenca F, Greciano O, Gunaratnam M, Haider S, Munnur D, Nanjunda R, Wilson WD, Neidle S.
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.
Bioorg Med Chem Lett. 2008 Mar 1;18(5):1668-73. Epub 2008 Jan 18.


Zagotto G, Sissi C, Moro S, Ben DD, Parkinson GN, Fox KR, Neidle S, Palumbo M.
Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives.
Bioorg Med Chem. 2008 Jan 1;16(1):354-61. (Epub 2007 Sep 25)










Our work is supported by Cancer Research UK , The Association for International Cancer Research , The European Union and BBSRC.
We are based at The School of Pharmacy
Copyright © 2008 Cancer Research UK Biomolecular Structure Group